Amadeu Llebaria

The paper investigates D1/D2-SPN balance in FXS mice and shows that mGlu4 facilitation rescues social deficits.

This paper develops photocaged chloroquine derivatives that inhibit autophagy in cancer stem cells upon light activation, showing effective cytotoxicity and spatiotemporal control.

The paper shows that mGlu5 expression is asymmetrically distributed in the hippocampus of wild-type mice, and this asymmetry is lost in AD model mice, with left-specific inhibition of mGlu5 restoring memory and reversing pathology.

This study captures time-resolved structures of β2AR modulated by a photoswitchable beta-blocker, revealing conformational changes linked to ligand isomerization and receptor function.

This paper develops a photoswitchable positive allosteric modulator of mGlu5 that activates the receptor in response to light, demonstrating reversible isomerization and light-dependent activity.

This study reports cryoEM structures of mGlu5 receptor with different PAMs, showing how PAM binding modulates receptor conformation and function.

The paper uses light-sensitive drugs to show that mGlu5 receptor blockade in specific brain regions has different effects on pain, with some areas reducing analgesia and others enhancing it.

This paper designs a low-cost photomodulator for in vivo photoactivation of a mGluR5 inhibitor, demonstrating its effectiveness in reducing pain response in rats.

This study shows that activating mGlu4 receptors in the amygdala reduces neuropathic pain symptoms in mice, with differential effects based on the side of activation.

The paper develops fast photoswitchable ligands for controlling neuronal activity in the cochlea, enabling rapid and sustained photocontrol without genetic modification.