Miguel Ángel Peña-Ortiz

This study shows that perinatal loss of ATRX in microglia leads to chronic reactivity and turnover but does not affect cognitive or social functions.

This study shows that astrocytic ATRX loss leads to neuronal dysfunction and long-term memory deficits through metabolic and synaptic pathway dysregulation.

This study shows that deleting ATRX in microglia disrupts chromatin structure, leading to viral mimicry and cognitive deficits in memory tasks.

This study shows that ATRX loss in oligodendrocyte progenitor cells causes myelination deficits and promotes astrocyte-like features, highlighting ATRX's role in myelination and glial cell fate.

This paper describes a method for isolating mouse glial nuclei with minimal processing steps, enabling reliable downstream omics analyses like ATAC-seq and RNA-seq.