Keyao Chen

This paper describes the generation of genetically-defined murine hepatoblastoma cell lines with angiogenic potential and reports their tumorigenic properties and drug sensitivities.

This paper describes the generation of isogenic murine hepatoblastoma cell lines with defined oncogenic drivers, which retain tumorigenicity and express endothelial markers under hypoxic conditions.

The paper identifies Gas1 as a suppressor of hepatoblastoma tumorigenesis by showing its restoration inhibits tumor growth in mice and cell lines, and identifies a common set of B-Y-N regulated genes.