Ethan Paulаkonis

This study identifies how STUB1 mutations in SCA48 disrupt co-chaperone and ligase functions in a domain-specific manner, leading to clinical heterogeneity.

This study examines how phosphorylation at HSP70 T636 affects its binding to CHIP, showing reduced affinity and altered interactions with other co-chaperones, with implications for disease.

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.