BioengineeringJournal of Immunological MethodsPeer-reviewed
Miniaturized CAR knocked onto CD3epsilon extends TCR function with CAR specificity under control of endogenous TCR signaling cascade
Katrin Manske, Lisa Dreßler, Simon P. Fräßle…·Mateusz P. Poltorak
This paper describes a method to miniaturize CAR T cells by integrating only the antigen-binding domain under the control of the endogenous TCR signaling cascade, preserving TCR function while enabling CAR specificity.