Author

Mateusz P. Poltorak

Bristol-Myers Squibb (Germany)

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Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Christian StembergeriD· 1 shared Claudia Tschulik· 1 shared Dirk Hans BuschiD· 1 shared Eileen Benke· 1 shared Katrin Manske· 1 shared Kilian SchoberiD· 1 shared Lisa DreßleriD· 1 shared Lothar Germeroth· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBioengineering

Christian StembergerORCID

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1 paper

Recent·Most cited

BioengineeringJournal of Immunological MethodsPeer-reviewedJan 11, 2024

Miniaturized CAR knocked onto CD3epsilon extends TCR function with CAR specificity under control of endogenous TCR signaling cascade

Katrin Manske, Lisa Dreßler, Simon P. Fräßle…·Mateusz P. Poltorak

This paper describes a method to miniaturize CAR T cells by integrating only the antigen-binding domain under the control of the endogenous TCR signaling cascade, preserving TCR function while enabling CAR specificity.

7 citations

humangenetic perturbation / CRISPR

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