Author

Tyler G. Southam

University of UtahORCID 0009-0003-5792-0967Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:protein folding & dynamics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:simulation· 1

Frequent Co-Authors

Jessica M. J. SwansoniD· 2 shared Alexander Daum· 1 shared Hannah Weckel-DahmaniD· 1 shared Maxwell He· 1 shared Myongin OhiD· 1 shared Ryan CarlseniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

Jessica M. J. SwansonORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJul 29, 2026

Asymmetry and Allostery: Insights into the Mechanism of Directional Peptide Translocation in AAA+ Unfoldases

Tyler G. Southam, Myongin Oh, Jessica M. J. Swanson

This study uses simulations and biochemical assays to show how structural asymmetry and allosteric networks in AAA+ unfoldases generate directional motion through kinetic asymmetry during ATP hydrolysis.

DOI 10.64898/2026.07.27.741010

cryo-EMsimulation

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BiophysicsJournal of Chemical Theory and ComputationPeer-reviewedMar 18, 2025

Ion Channel Reaction Networks: Dielectric Screening and the Importance of Off-Pathway Flux

Hannah Weckel-Dahman, Ryan Carlsen, Alexander Daum…·Jessica M. J. Swanson

This paper uses multiscale responsive kinetic modeling to study ion channel mechanisms, showing that off-pathway flux and dielectric screening significantly influence current profiles and channel behavior.

5 citations

electrophysiologydeep learning

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