Alexander L. Kley

This study shows hypoxia promotes metastasis in pancreatic cancer by suppressing Kdm8, leading to epigenetic and transcriptomic changes, increased chromosomal instability, and metastatic disease.

The paper identifies regulatory T cells suppressing tissue-resident CD8+ T cell programs in early melanoma, revealing a mechanism of immune evasion.

This study identifies AP-1 transcription factors as key regulators of TRM development across tissues using scRNA-seq and ATAC-seq, revealing a novel mechanism for TRM reactivation.