Jieye Lin

This study identifies two polymorphic structures of oxyacanthine dihydrochloride monohydrate using MicroED, revealing conformational differences and thermodynamic preferences.

This study uses high-throughput MicroED to analyze structural dynamics of NaK and NaK2CNG ion channels, revealing sodium binding and dynamic selectivity filter behavior.

This study develops a workflow combining cocktail soaking with automated microED to enable rapid ligand screening and structure determination from microcrystals, validated with known and novel ligand interactions.

This study uses MicroED and DFT to determine the 3D structures of fluticasone furoate and propionate in different states, revealing conformational changes and their functional implications.

This study determines the 3D structure of oxybutynin hydrochloride using MicroED and reveals insights into its binding mechanism with the M3 muscarinic receptor.

This study uses MicroED and molecular docking to determine the atomic structures and binding mechanisms of five common antidepressants from commercial powder samples.

This study determines the 3D crystal structure of meclizine dihydrochloride using MicroED and reveals its binding mechanism to the histamine H1 receptor through molecular docking.