Cancer BiologyCancer Research CommunicationsPeer-reviewed
A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC
Yusuke Goto, Keiichi Koshizuka, Toshinori Ando…·Jorge Silvio Gutkind
This study identifies mTOR inhibition as a way to prevent adaptive resistance to CDK4/6 blockade in HNSCC by targeting cell cycle pathways.
12 citations