ImmunologybioRxivPreprint
CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites
Christina Verbruggen, Leon Gehrke, Nicole Banholzer…·Markus Sauer
This study uses super-resolution microscopy to show CARs form nanodomains on T-cell membranes, accumulating at tumor sites, with transposon-engineered CARs showing higher density and faster anti-tumor activity.