Integrative transcriptomics and electrophysiological profiling of hiPSC-derived neurons identifies novel druggable pathways in Koolen-de Vries Syndrome
Anouk H. A. Verboven, Sofía Puvogel, Brooke L. Latour…·Nael Nadif Kasri
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Max Planck Institute for PsycholinguisticsORCID 0009-0004-6630-2148Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Anouk H. A. Verboven, Sofía Puvogel, Brooke L. Latour…·Nael Nadif Kasri
Zoe H. Mitchell, Joery den Hoed, Willemijn J. J. Claassen…·Marco Trizzino
This study shows CHD3 regulates BMP signaling during cranial neural crest cell specification by modulating chromatin accessibility and gene expression.
Joery den Hoed, Maggie M. K. Wong, Willemijn J. J. Claassen…·Simon E. Fisher
This study investigates the role of CHD3 in human brain development using genetically modified organoids, finding it regulates synaptic development genes without affecting early neurogenesis.