Author

Weifang Wu

Fred Hutch Cancer CenterORCID 0009-0004-7676-4151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CUT&Tag· 1

Frequent Co-Authors

Kami AhmadiD· 2 shared Steven HenikoffiD· 2 shared Charles Grenfell MullighaniD· 1 shared Danielle C. KirkeyiD· 1 shared Derek H. JanssensiD· 1 shared Dominik J. OttoiD· 1 shared Jacob E. GreeneiD· 1 shared Jay F. SarthyiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenomics

Kami AhmadORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 9, 2026

✦ In-depth digest

KAS-CUT&Tag for direct mapping of transcription bubbles

Weifang Wu, Jacob E. Greene, Kami Ahmad, Steven Henikoff

N3-kethoxal labeling of single-stranded DNA within CUT&Tag maps Pol II transcription bubbles; bubble density tracks nascent transcription, shifts with transcription inhibitors and TFIIS loss, and peaks at histone genes.

1 citation

humanCUT&Tag

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Cancer BiologyNature CommunicationsPeer-reviewedOct 29, 2024

KMT2A oncoproteins induce epigenetic resistance to targeted therapies

Derek H. Janssens, Melodie Duran, Dominik J. Otto…·Steven Henikoff

This study shows KMT2A oncoproteins drive lineage-switching and epigenetic resistance in leukemia by dynamically binding chromatin and persisting as ENL-marked lesions despite therapy.

18 citationstop 4%

humanChIP-seq

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