Author

Lauren Borho

University of PittsburghORCID 0009-0005-1253-5322Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam G. ChatoffiD· 2 shared Aidan R. ColeiD· 2 shared Amandine AmalriciD· 2 shared Andrea Andress HuacachinoiD· 2 shared Apoorva UbovejaiD· 2 shared Baixue YangiD· 2 shared Benjamin Guy BitleriD· 2 shared Esther ElishaeviD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Adam G. ChatoffORCID

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2 papers

Recent·Most cited

Cancer BiologyNature AgingPeer-reviewedJul 30, 2026

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

Aidan R. Cole, Raquel Buj, Apoorva Uboveja…·Katherine M. Aird

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

6 citationstop 3%

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyNaturePeer-reviewedMay 27, 2026

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

Apoorva Uboveja, Baixue Yang, Raquel Buj…·Katherine M. Aird

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

10 citations

humanproteomics

𝕏 PostBluesky