Author

Dominic T. Castanzo

University of California, BerkeleyORCID 0009-0005-2974-4737Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:protein structure· 1 Assay:structural biology· 1 Organism:yeast· 1

Frequent Co-Authors

Andreas MartiniD· 1 shared Bashir A. AliiD· 1 shared Baylee A. SmithiD· 1 shared Brooke M. GardneriD· 1 shared Chris D. RichardsoniD· 1 shared Christopher T. BrowniD· 1 shared Cindy J. CastelleiD· 1 shared Cristina N. ButterfieldiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

Andreas MartinORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistryNature Structural & Molecular BiologyPeer-reviewedApr 13, 2026

Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency

Kaoling Guan, Rodrigo Fregoso Ocampo, Paula B. Matheus Carnevali…·David Ward Taylor

The paper compares Cas12f orthologs to identify mechanistic features that enhance genome editing efficiency in human cells.

5 citationstop 2%

humanexperimental assay

𝕏 PostBluesky

BiochemistryProtein Expression and PurificationPeer-reviewedApr 28, 2025

Overcoming Fluorescence Loss in mEOS-based AAA+ Unfoldase Reporters Through Covalent Linkage

Isabella Walter, Baylee A. Smith, Dominic T. Castanzo, Matthew L. Wohlever

The paper develops a method to use mEOS-based reporters for membrane-associated AAA+ unfoldases by covalently linking mEOS to a degron via Sortase, preserving fluorescence and enabling functional analysis.

DOI 10.1016/j.pep.2025.106724

protein structureexperimental assay

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BiochemistryJournal of Biological ChemistryPeer-reviewedNov 29, 2023

The Pex6 N1 domain is required for Pex15 binding and proper assembly with Pex1

Bashir A. Ali, Ryan M. Judy, Saikat Chowdhury…·Brooke M. Gardner

This study identifies the Pex6 N1 domain's role in binding Pex15 and stabilizing the Pex1/Pex6 heterohexamer, essential for peroxisome function.

6 citations

yeaststructural biology

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