Author

Flowreen Shikwana

University of California, Los AngelesORCID 0009-0006-5464-6335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Keriann M. BackusiD· 2 shared Alexandra C. TurmoniD· 1 shared Alexey I. NesvizhskiiiD· 1 shared Ashley R. JulioiD· 1 shared Cindy C. Truong· 1 shared Elaine F. ReediD· 1 shared Emil R. Dominguez· 1 shared Fengchao YuiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Keriann M. BackusORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedOct 28, 2024

Multi-omic stratification of the missense variant cysteinome

Heta S. Desai, Katrina H. Andrews, Kristina V. Bergersen…·Keriann M. Backus

This paper uses chemoproteogenomics to identify gain-of-cysteine variants in cancer and healthy genomes, revealing their prevalence and potential for drug targeting.

24 citations

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintOct 30, 2023

Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds

Ashley R. Julio, Flowreen Shikwana, Cindy C. Truong…·Keriann M. Backus

The paper identifies a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14, showing it causes protein aggregation, depletion, and stress granule formation in cells.

8 citations

humanproteomics

𝕏 PostBluesky