Author

Gary Birsen

InsermORCID 0009-0007-3534-1007Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Audrey Mansuet‐LupoiD· 2 shared Diane DamotteiD· 2 shared Emmanuel DonnadieuiD· 2 shared Irena Rajnpreht· 2 shared Lene VimeuxiD· 2 shared Adrien RouaultiD· 1 shared Alice MachadoiD· 1 shared Aurélie Thomas· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Audrey Mansuet‐LupoORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 28, 2026

Safety profiling of CAR-T cells using an organotypic human tissue platform

Alice Machado, Gary Birsen, Irena Rajnpreht…·Emmanuel Donnadieu

This paper develops an organotypic human tissue platform to assess CAR-T cell toxicity and shows it can predict tissue-specific toxicity profiles and identify factors influencing off-tumor effects.

DOI 10.64898/2026.07.25.740527

humanexperimental assay

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ImmunologyNature CommunicationsPeer-reviewedMar 11, 2024

Mitochondrial metabolism sustains CD8+ T cellmigration for an efficient infiltration into solid tumors

Luca Simula, Mattia Fumagalli, Lene Vimeux…·Emmanuel Donnadieu

This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.

98 citationstop 1%

humanbulk RNA-seq

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