Ljiljana Mihajlovic

This paper develops a genetic toolkit for Bdellovibrio bacteriovorus to modulate gene expression and protein secretion, enhancing its potential for bioengineering and research applications.

This study experimentally tests Ohno's hypothesis by evolving fluorescent protein genes in E. coli, finding that double-copy populations show increased mutational robustness and diversity but not accelerated phenotypic evolution.

The paper shows that different gene regulatory networks in E. coli constrain phenotypic variation differently, even when producing the same phenotype.