Cancer BiologyCell Death DiscoveryPeer-reviewed
HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma
Julie Contenti, Yongjian Guo, Magalie Larcher…·Nathalie M. Mazure
This study shows that Group 3 medulloblastoma cells rely on HIF-2 instead of HIF-1 for hypoxia adaptation, and inhibiting HIF-2 with metformin kills these cells more effectively than non-Group 3 cells.
9 citations