Lucas J. Handlin

This study investigates how cholesterol modulates HCN channels in DRG neurons through sequential membrane remodeling, showing distinct effects in naive and neuropathic conditions.

The paper identifies intermediate voltage-sensor conformations in hERG channels caused by LQTS-associated mutations using FLIM, tmFRET, and MD simulations.

This study identifies RhoA's role in modulating ordered membrane domains (OMDs) under stress, linking cytoskeletal changes to membrane mechanics and neuropathic pain.

The paper shows that lipid nanodomains modulate HCN channels in DRG neurons, affecting pain signaling and neuronal firing.