Abena Dwamena

This paper uses single-nucleus RNA-seq to map transcriptional changes in 5xFAD mouse brains, identifying VIP interneurons as the most vulnerable and showing rolipram's preferential rescue effect through Pde7b/CREB1 signaling.

This study shows that homeostatic activation of 26S proteasomes by PKA protects against brain and cardiac dysfunction in Alzheimer's disease mice.

This study shows that disrupting FOXO4 function reduces oxidative stress and neuronal injury in ischemia-reperfusion conditions, suggesting it as a therapeutic target for stroke.

This study shows that impaired proteasome in mouse brains leads to mitochondrial DNA release, activates the cGAS-STING pathway, and causes necroptosis, contributing to neuroinflammation and neurodegeneration.