BioengineeringMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewed
Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence
Dan Cappabianca, Dan L. Pham, Matthew H. Forsberg…·Krishanu Saha
This study shows that metabolic priming during CAR T cell manufacturing reduces glycolysis and enhances memory phenotypes, improving in vivo persistence against GD2+ tumors.
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