Author
University Health NetworkORCID 0009-0009-9639-4836Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Qiang Liu, Milena Gojsevic, Angelica Varesi…·Jean CY Wang
This study shows that PLK1 inhibition eradicates quiescent leukemia stem cells through a non-canonical mechanism involving microtubule and endolysosomal disruption, distinct from its canonical mitotic function.
Angelica Varesi, Sontago Dong, Chiara Gaddoni…·John E. Dick
This study identifies locus-specific transposable elements driving VEXAS syndrome pathophysiology by regulating myeloid commitment in UBA1-mutant hematopoietic stem cells.
Andy G.X. Zeng, Murtaza S. Nagree, Niels Asger Jakobsen…·Stephanie Zhi-Juan Xie
The paper identifies a human HSC subset with inflammatory memory that accumulates with age and clonal hematopoiesis, potentially increasing cancer and infection risks.
Joana L. Araújo, Elvin Wagenblast, Véronique Voisin…·John Edgar Dick
This study shows FLT3 is essential for ITD-mutated leukemic stem cells but not for normal hematopoietic stem cells, supporting targeted therapies for AML.
Boyang Zhang, Alexander J. Murison, Angelica Varesi…·Stanley W.K. Ng
This study identifies distinct gene regulatory networks in hematopoietic stem cells and leukemia stem cells using integrated gene expression and chromatin accessibility data from AML patients and human umbilical cord blood.