John Edgar Dick

A combined program of induced stemness and differentiation in response to interferon gamma drives acute myeloid leukaemia growth

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

CD59 organizes the plasma membrane to sustain oncogenic Ras-MAPK signaling and is a targetable vulnerability in acute myeloid leukemia

This study identifies CD59 as a critical regulator of Ras-MAPK signaling in AML, showing its depletion impairs leukemic growth and identifies rILYd4 as a potential therapeutic target.

Locus-specific transposable element expression drives human hematopoietic stem cell disease pathophysiology

This study identifies locus-specific transposable elements driving VEXAS syndrome pathophysiology by regulating myeloid commitment in UBA1-mutant hematopoietic stem cells.

Ex Vivo Expansion of Hematopoietic Stem and Progenitor Cells from Human Mobilized Peripheral Blood for Gene Therapy Applications

This study optimizes an ex vivo expansion protocol for mobilized peripheral blood HSCs, enabling robust gene therapy applications with long-term engraftment.

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy

This study shows that hematopoietic Tet2 inactivation improves immune checkpoint blockade response in mice and is associated with better clinical outcomes in melanoma patients with TET2-driven clonal hematopoiesis.

A Rapid Gene Expression Profiler Classifies AML Tumor Responsiveness to Standard Therapies

This paper develops a rapid qPCR-based gene expression profiler to predict AML patient response to standard therapies using cell state and BCL2 family gene expression signatures.

ATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity

The paper identifies ATP2B1 as a marker for human LT-HSC subpopulations with distinct repopulation and self-renewal capacities across ontogeny.

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

This study shows FLT3 is essential for ITD-mutated leukemic stem cells but not for normal hematopoietic stem cells, supporting targeted therapies for AML.

Stress Granules Underlie Acute Myeloid Leukemia Stem Cell Survival and Stress Adaptation

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.

Distinct gene regulatory networks govern hematopoietic and leukemia stem cells

This study identifies distinct gene regulatory networks in hematopoietic stem cells and leukemia stem cells using integrated gene expression and chromatin accessibility data from AML patients and human umbilical cord blood.

Reconstructing complex cancer evolutionary histories from multiple bulk DNA samples using Pairtree

Pairtree reconstructs clone trees from multiple bulk DNA samples to infer cancer evolutionary histories with higher accuracy and scalability.

SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes derived data

SmMIP-tools processes and analyzes smMIP-derived sequencing data, enabling accurate variant detection and improving accessibility to smMIP technology for genetic research.

Quantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies

The paper presents a workflow for single-cell proteomics to study cellular heterogeneity in leukemia, demonstrating the ability to quantify thousands of proteins per cell.

Functional Profiling of Single CRISPR/Cas9-Edited Human Long-Term Hematopoietic Stem Cells

The paper develops a method to efficiently edit LT-HSCs at single-cell resolution and demonstrates distinct functional outcomes of GATA1 editing.

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

This study identifies 14 genome-wide significant loci and a polygenic signature for myeloproliferative neoplasms, implicating hematopoietic stem cell function and self-renewal in disease risk.