Stephanie Zhi-Juan Xie

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

This study shows that THPO protects HSCs from inflammatory stress by maintaining membrane lipid integrity and suppressing STAT1-driven pyroptosis.

This study identifies CD59 as a critical regulator of Ras-MAPK signaling in AML, showing its depletion impairs leukemic growth and identifies rILYd4 as a potential therapeutic target.

This study identifies locus-specific transposable elements driving VEXAS syndrome pathophysiology by regulating myeloid commitment in UBA1-mutant hematopoietic stem cells.

This study optimizes an ex vivo expansion protocol for mobilized peripheral blood HSCs, enabling robust gene therapy applications with long-term engraftment.

This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.

The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.

The paper identifies ATP2B1 as a marker for human LT-HSC subpopulations with distinct repopulation and self-renewal capacities across ontogeny.

This study identifies distinct gene regulatory networks in hematopoietic stem cells and leukemia stem cells using integrated gene expression and chromatin accessibility data from AML patients and human umbilical cord blood.

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

The paper identifies a human HSC subset with inflammatory memory that accumulates with age and clonal hematopoiesis, potentially increasing cancer and infection risks.