In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities

Anne Yau; Maxwell Landolina; Mari Anne Snow; Pinar Mesci; Brandon Williams; James B. Hoying; Jana Stoudemire; Rayyanah Barnawi; Peggy A. Whitson; Rose Hernandez; Derek Duflo; Honglu Wu; Yupeng Chen

doi:10.1038/s41526-025-00482-z

Bioengineeringnpj MicrogravityJul 2, 2025

Peer-reviewed journal article

In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities

Anne Yau iD, Maxwell Landolina, Mari Anne Snow, Pinar Mesci iD, Brandon Williams, James B. Hoying iD, Jana Stoudemire iD, Rayyanah Barnawi, Peggy A. Whitson, Rose Hernandez, Derek Duflo, Honglu Wu, Yupeng Chen iD

Abstract

In-space manufacturing of nanomaterials is a promising concept while having limited successful examples. DNA-inspired Janus base nanomaterials (JBNs), used for therapeutics delivery and tissue regeneration, are fabricated via a controlled self-assembly process in water at ambient temperature, making them highly suitable for in-space manufacturing. For the first time, we designed and accomplished the production of JBNs on orbit during the Axiom-2 (Ax-2) mission demonstrating great promising and benefits of in-space manufacturing of nanomaterials.

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