B. Xia

Antimicrobial mechanism of in-situ plasma activated water treatment of pathogenic Escherichia coli and Staphylococcus aureus biofilms

This study investigates how plasma-activated water inactivates biofilms of E. coli and S. aureus by disrupting their matrix and membrane, leading to increased ROS/RNS and reduced biomass.

scRNA-seq reveals transcriptional dynamics of Encephalitozoon intestinalis parasites in human macrophages

This study uses scRNA-seq to analyze transcriptional changes in human macrophages and Encephalitozoon intestinalis parasites during infection, revealing parasite developmental dynamics and host response.

Transcriptional Signatures Associated with the Survival of Escherichia coli Biofilm During Treatment with Plasma-Activated Water

This study identifies transcriptional changes in E. coli biofilms exposed to plasma-activated water, revealing key genes and pathways involved in their survival and response to oxidative stress.

Discrimination of Isomeric Glycans via High-sensitive Engineered Nanopore

This paper designs an engineered nanopore to distinguish isomeric glycans with high sensitivity and achieves over 90% separation accuracy without machine learning.

Human microbiota is a reservoir of SARS-CoV-2 advantageous mutations

The paper identifies that the human microbiota contributes to SARS-CoV-2 mutations by replicating bacterial mRNAs with advantageous mutations, leading to chimeric RNAs and altered viral properties.

Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy

This study shows EHMT1 and EHMT2 have distinct roles in cancer therapy, with EHMT1 affecting DNA replication and alkylating agents, while EHMT2 influences immunotherapy response via STING expression.

Tick hemocytes have pleiotropic roles in microbial infection and arthropod fitness

This study identifies hemocyte heterogeneity and pleiotropic roles in ticks using multi-omics approaches, revealing their impact on immunity, metabolism, and arthropod fitness.

Plasma Activated Water as a Pre-Treatment Strategy in the Context of Biofilm-Infected Chronic Wounds

This study evaluates Plasma Activated Water (PAW) as a pre-treatment to enhance antiseptic efficacy against biofilms in chronic wounds.

Bestrophin-4 relays Hes4 and interacts with Twist1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

This study identifies BEST4 as a tumor suppressor in colorectal cancer that interacts with Hes4 to inhibit EMT and metastasis.

Determinants of Disordered Protein Co-Assembly Into Discrete Condensed Phases

The paper identifies sequence determinants of IDR co-assembly into distinct condensed phases and reveals physicochemical principles governing phase separation specificity.

Inspiration of SARS-CoV-2 envelope protein mutations on pathogenicity of Omicron XBB

The paper analyzes SARS-CoV-2 envelope protein mutations across Omicron sub-variants to assess their impact on pathogenicity, finding that certain mutations correlate with reduced disease severity.

An effective sanitizer for fresh produce production: In situ plasma activated water treatment inactivates pathogenic bacteria and maintains the quality of cucurbit fruit

This paper demonstrates that plasma activated water (PAW) effectively reduces pathogenic bacteria on cucurbit fruits while maintaining quality and shelf life, outperforming sodium hypochlorite in some aspects.

Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters.

The paper identifies a mutation in the SARS-CoV-2 Omicron variant's structural envelope protein that reduces ion channel calcium permeability and acid sensitivity, leading to lower cell damage and cytokine production.

Recurrence of cancer cell states across diverse tumors and their interactions with the microenvironment

The paper identifies recurrent cancer cell states across 15 tumor types and examines their interactions with the tumor microenvironment using single-cell RNA-Seq and spatial transcriptomics.

The genetic basis of tail-loss evolution in humans and apes

This paper identifies an Alu element insertion in the TBXT gene as the genetic mechanism driving tail-loss evolution in hominoids, showing it causes alternative splicing and tail absence in mice.

Comparison of heat-inactivated and infectious SARS-CoV-2 across indoor surface materials shows comparable RT-qPCR viral signal intensity and persistence

This study compares RT-qPCR signal intensity and persistence of heat-inactivated and infectious SARS-CoV-2 on different surfaces, showing similar decay patterns and enabling simplified environmental monitoring protocols.

Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue Cells

This study shows that chemo-mechanical cues influence chromatin organization in connective tissue cells, with disease disrupting this relationship.

Mass cytometry reveals immunological response to radiation-induced cardiac fibrosis in mice

This study uses mass cytometry to analyze immunological changes in mice after radiation-induced cardiac fibrosis, finding increased macrophages and pro-fibrotic cytokines.

Development of A Decellularized Meniscus Matrix-Based Nanofibrous Scaffold for Meniscus Tissue Engineering

This paper develops a nanofibrous scaffold using decellularized meniscus matrix and synthetic polymers to enhance meniscus cell function and matrix production.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

Gene Panel Sequencing in a Chinese High-risk Breast Cancer Cohort

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

Widespread transcriptional scanning in the testis modulates gene evolution rates

The paper maps gene expression in human spermatogenesis and finds that expressed genes have fewer germline mutations, suggesting transcriptional scanning reduces DNA damage and influences gene evolution rates.