Lower pathogenicity but similar genital shedding of monkeypox virus clade Ib compared to clade Ia in a rodent model
Franziska Karola KaiseriD, Shane GalloglyiD, Reshma Koolaparambil MukeshiD, Missiani OchwotoiD, Claude Kwe YindaiD, Sarah van ToliD, Jonathan Schulz, Kailin Hawes, Brown BullochiD, Anthony McBain, Trenton BushmakeriD, Atsushi OkumuraiD, Jessica Prado-SmithiD, Brian J. SmithiD, Kyle RosenkeiD, Greg Saturday, Vincent Jacobus MunsteriD
Abstract
We compared clinical disease, virus shedding and dissemination following genital MPXV clade Ia and Ib infections in Mastomys natalensis. MPXV clade Ib resulted in a milder clinical disease but a similar shedding profile to clade Ia. These findings indicate a prolonged pre-symptomatic or prodromal shedding period in clade Ib infections.
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