Infection of ratites with clade 2.3.4.4b HPAIV H5N1: Potential implications for zoonotic risk
Holly A. CoombesiD, Jacob Terrey, Audra-Lynne D. SchlachteriD, Phoebe McCarter, Isabella Regina, Richard Hepple, Natalie McGinn, James SeekingsiD, Jayne Cooper, Benjamin Clifton, Benjamin C. MollettiD, Marco Falchieri, Alejandro NúñeziD, Scott M. ReidiD, Joe JamesiD, Ashley C. BanyardiD
Abstract
We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea (Rhea americana). Viral genetic analysis revealed the mammalian associated PB2-E627K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotising inflammation, and a strong vasculotropism.
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