Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model
C. Herate, R. Marlin, F. Touret, N. D. Bosquet, F. Donati, F. Relouzat, L. Junges, M. Galhaut, O. Dehan, Q. Sconosciutti, A. Nougairede, X. de Lamballerie, S. van der Werf, R. Le Grand
Abstract
The SARS-CoV2 Omicron variants have acquired new Spike mutations leading to escape from the most of the currently available monoclonal antibody treatments reducing the options for patients suffering from severe Covid-19. Recently, both in vitro and in vivo data have suggested that Sotrovimab could retain partial activity against recent omicron sub-lineage such as BA.5 variants, including BQ.1.1. Here we report full efficacy of Sotrovimab against BQ.1.1 viral replication as measure by RT-qPCR in a non-human primate challenge model.
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