This study uses high-throughput screening to identify small molecule inhibitors that block coronavirus entry, finding a novel broad-spectrum antiviral.

bioRxiv · Dec 4, 2023Microbiology

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 Omicron sub-lineages

F. Touret, E. Giraud, J. Bourret, F. Donati, J. Tran-Rajau, J. Chiaravalli, F. Lemoine, F. Agou, E. Simon-Loriere, S. Van Der Werf, X. de Lamballerie

This study evaluates the neutralizing activity of monoclonal antibodies against SARS-CoV-2 Omicron sub-lineages and finds reduced efficacy against several variants.

bioRxiv · Dec 22, 2022Microbiology

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

C. Planchais, I. Fernandez, T. Bruel, G. Dias de Melo, M. Prot, M. Beretta, P. Guardado-Calvo, J. Dufloo, L. M. Molinos-Albert, M. Backovic, J. Chiaravalli, E. Giraud, B. Vesin, L. Conquet, L. Grzelak, , H. Mouquet

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

bioRxiv · Apr 1, 2022Immunology

Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness

E. Giraud, H. Varet, R. Legendre, O. Sismeiro, F. Aubry, S. Dabo, L. B. Dickson, C. Valiente Moro, L. Lambrechts

This study shows that larval exposure to specific bacteria in mosquitoes alters lipid metabolism, affecting adult survival and fitness.

bioRxiv · May 20, 2021Microbiology

Genetics of nodulation in Aeschynomene evenia uncovers new mechanisms of the rhizobium-legume symbiosis

J. Quilbe, L. Lamy, L. Brottier, P. Leleux, J. Fardoux, R. Rivallan, T. Benichou, R. Guyonnet, M. Becana, I. Villar, O. Garsmeur, B. Hufnagel, A. Delteil, D. Gully, C. Chaintreuil, , J.-F. ARRIGHI

This study identifies key genes involved in nodulation in Aeschynomene evenia, revealing new mechanisms of rhizobium-legume symbiosis through genetic and transcriptomic analyses.

bioRxiv · Nov 26, 2020Plant Biology

Global biogeographical regions of freshwater fish species

B. Leroy, M. S. Dias, E. Giraud, B. Hugueny, C. Jezequel, F. Leprieur, T. Oberdorff, P. A. Tedesco

This study defines major biogeographical regions and transition zones for freshwater fish species using a global database of species occurrences.

bioRxiv · Jun 12, 2019Ecology

A phylogenetic framework of the legume genus Aeschynomene for comparative genetic analysis of the Nod-dependent and Nod-independent symbioses

L. Brottier, C. Chaintreuil, P. Simion, C. Scornavacca, R. Rivallan, P. Mournet, L. Moulin, G. P. Lewis, J. Fardoux, S. C. Brown, M. Gomez-Pacheco, M. Bourges, C. Hervouet, M. Gueye, R. Duponnois, , J.-F. Arrighi

This paper constructs a phylogeny of Aeschynomene legumes to study Nod-dependent and Nod-independent symbioses, identifying suitable species for comparative genetic analysis.

bioRxiv · Sep 21, 2018Plant Biology