Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Jasper Panten; Stefania Prete; James Cleland; Lauren M. Saunders; Job van Riet; Anja Schneider; Paul Adrian Ginno; Nina Schneider; Marie-Luise Koch; Xuqi Chen; Moritz Gerstung; Oliver Stegle; Arthur P. Arnold; James M. A. Turner; Édith Heard; Duncan T. Odom

doi:10.1038/s41467-024-52640-8

GeneticsNature CommunicationsOct 11, 2024

Peer-reviewed journal article

Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Jasper Panten iD, Stefania Prete iD, James Cleland iD, Lauren M. Saunders iD, Job van Riet iD, Anja Schneider iD, Paul Adrian Ginno iD, Nina Schneider, Marie-Luise Koch iD, Xuqi Chen iD, Moritz Gerstung iD, Oliver Stegle iD, Arthur P. Arnold iD, James M. A. Turner iD, Édith Heard iD, Duncan T. Odom iD

Abstract

The Four Core Genotypes (FCG) is a mouse model system heavily used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of multiple genes including the auto-immune master regulator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on FCG mice.

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