Author

Manu Rangachari

axe Neurosciences, Centre de recherche du CHU de Québec-Université Laval, Pavillon CHUL, 2705 boulevard Laurier, Quebec City, QC G1V 4G2, Canada;ORCID 0000-0002-7065-3803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Irshad AkbariD· 2 shared Joanie Baillargeon· 2 shared Mohamed Reda FazaziiD· 2 shared Prenitha Mercy Ignatius Arokia Doss· 2 shared Alexia Falle· 1 shared Ana C. Anderson· 1 shared Ana Carrizosa AndersoniD· 1 shared Arnaud DroitiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Irshad AkbarORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 11, 2026

The antagonism of sex chromosomes and sex hormones dictates outcomes in Th17 cell-mediated central nervous system autoimmunity.

Muhammad Umair, Joanie Baillargeon, Charles Joly-Beauparlant…·Manu Rangachari

This study shows that sex hormones and sex chromosomes have opposing effects on Th17 cell-mediated autoimmunity in mice, with hormones reducing disease severity and chromosomes increasing it.

DOI 10.64898/2026.11.09.765425

mouseexperimental assay

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ImmunologyThe Journal of ImmunologyPeer-reviewedMay 1, 2026

Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner.

Irshad Akbar, Prenitha Mercy Ignatius Arokia Doss, Preya Patel…·Manu Rangachari

This study shows that CD8+ T cells can drive chronic CNS autoimmunity in a CD4+ T cell-dependent manner through Th17-like differentiation and cytokine production.

2 citationstop 2%

mouseexperimental assay

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