biophysical modeling

This study reveals the structural basis of RanGAP1 regulation and catalysis in nuclear transport, showing how sumoylation and conformational changes coordinate GTP hydrolysis.

This paper shows YpeB inhibits SleB in dormant Bacillus subtilis spores through direct interaction, preventing premature cortex degradation.

This paper develops a coupled Maxwell-electromagnetic cable framework to model action potential propagation in branched axons, showing electromagnetic effects significantly impact conduction and bifurcation transmission.

This paper analyzes the evolution and functional diversification of the WhiG sigma factor in Actinomycetota, revealing two distinct clades with different regulatory mechanisms and expanded biological roles.

This study identifies an atypical BlaIR system, pvmSR, in Pseudomonas aeruginosa that regulates virulence but not β-lactam resistance, using C. elegans as a model.

The paper identifies a lipid-gated mechanism in CRISPR-Cas systems that uses membrane depolarization to block viral replication.

This study compares the thermodynamic behavior of glucose translocation in GLUT4 using Cryo-EM and AlphaFold models, revealing structural limitations in AI-generated models.

This paper shows that SARS-CoV-2's Nsp5 protease cleaves La protein to switch viral RNA from translation to replication.

This paper identifies pervasive integrative and conjugative elements (ICEs) in Porphyromonas gingivalis genomes, showing they contribute to strain-level gene diversity and virulence.

This study identifies the C-terminal domain of MmpL11 as required for its interaction with MSMEG_0240 using biotin proximity labeling assays in Mycobacterium smegmatis.

The paper identifies a RAC1-PLCγ2 axis that decodes EGFR ligand bias by linking receptor trafficking to metabolic programs supporting cell migration.

This study improves cross-presentation by using fusion-dependent mini-proteins to enhance antigen delivery to the dendritic cell cytosol, leading to better MHC-I presentation and T-cell activation.

This study identifies two distinct mechanisms by which Pkp4, a δ-catenin, is recruited to adherens junctions: one via cadherin binding and another via phospholipid-rich membrane domains.

The paper identifies 11 rules governing cooperativity in Paired-like homeodomain DNA binding and shows how disease variants disrupt this cooperativity.

The paper characterizes human TBCK as a class I pseudokinase through biochemical and biophysical analysis, revealing its catalytically inactive nature and structural features.

The paper identifies the APC - Asef1 - Cdc42 - N-WASP - Arp2/3 pathway as a mechanism by which microtubules regulate directional cell migration and neuron navigation through branched actin assembly at microtubule tips.

This paper determines the structure and dynamics of the non-canonical inflammasome using biophysical methods, showing it is heterogeneous and primed for rapid substrate cleavage.

The paper shows that dimeric UvrD-family helicases unwind DNA more efficiently when bulky lesions are on the displaced strand, suggesting a model where one subunit interacts with the displaced strand to promote processive unwinding.

This study shows that cooling reduces protein acetylation in adipocytes, affecting mitochondrial function and metabolism without changing enzyme expression or acetyl-CoA availability.

This study shows that Smc5/6 microtubule binding constrains chromatin dynamics and promotes pericentromeric folding in yeast, safeguarding genome stability during mitosis.

This study identifies miR-223-3p in extracellular vesicles as a biomarker for aortic dilation in Takayasu arteritis, outperforming traditional inflammatory markers.

Ymu1 TnpB unwinds DNA via a long-lived partially unwound intermediate before a rarely stable open state; the WFR triple variant stabilizes both, boosting plant editing.

The paper reports structures and binding data showing how a sperm protein recognizes divergent egg coat components through conserved interaction geometry and asymmetric binding dynamics.

The paper shows that disease mutations in dyskerin's N-terminal extension and α2-helix do not prevent dimerization but impair hTR binding, contributing to X-DC pathogenesis.

This study investigates reticulate evolution in neotropical Adiantum ferns using phylogenomic data and bioinformatic methods, revealing widespread hybridization and its impact on biodiversity and taxonomy.

This paper uses biophysical techniques to show that GT* binding to PDE6 induces a dynamic active state, revealing a previously unobserved conformation associated with catalysis.

This study identifies GP63 as a protease that activates aerolysin toxin in Leishmania major, revealing a mechanism of bacterial competition in the sandfly midgut.

This study investigates how mutations in Rac2 alter its conformational dynamics and signaling, revealing distinct inactive and overactive states that impact cellular function.

This study identifies key genes regulating potato tuber starch concentration across growth stages using sequencing and bioinformatics, finding a negative correlation between β-glucosidase activity and starch content.