biophysical modeling

The paper investigates IFT-A-IFT-B coordination in cilia using multiple techniques and finds that BBSome-IFT proximities are essential for their coupling.

This study shows non-coding RNA disrupts enhancer-promoter interactions when increased, and stabilizes them when decreased, independent of transcription initiation.

The paper identifies BCAS3 as a novel interactor of WIPI2b that regulates its membrane association through interaction with PtdIns3P.

The paper identifies SEC16A/MAG5 as essential for ABA receptor homeostasis by mediating ER export and trafficking, impacting ABA signaling without affecting ABA levels.

The paper shows that heat stress reverses the growth-promoting thermomorphogenesis pathway in Arabidopsis by suppressing auxin and PIF4 in cotyledons, revealing an active molecular mechanism.

The paper develops a biophysical model of the SCN to explain circadian rhythm splitting under chronic light and shows how E/I balance and chloride cotransporter dynamics drive this behavior.

This study shows lysenin pores induce membrane curvature into rigid dome-like structures, suggesting beta-PFTs alter host cell membranes beyond pore formation.

This study investigates how tau protein regulates motor proteins on microtubules using single-molecule imaging, cryo-EM, and MD simulations, revealing distinct mechanisms for inhibiting kinesin-1 and dynein.

This study identifies how PIP3 activates an ancestral Tec kinase by displacing its PH domain from an inhibitory interaction with its kinase domain.

This paper shows that horizontally acquired mgtC genes can have different physiological roles depending on genomic and biochemical contexts in Salmonella enterica and other bacteria.

This study reveals how PKR's dsRBDs work together to enable selective RNA recognition and activation through a two-step ligand sampling mechanism.

This study compares Zyxin and LPP's mechanoaccumulation at tricellular junctions under tension, revealing differences in their LIM domain sensing mechanisms.

This study identifies EF-Tu as a target of the Fic enzyme SoFic, showing AMPylation disrupts EF-Tu's switch-I region and inhibits translation, while SoFic also binds DNA, suggesting dual regulatory roles.

The paper identifies conserved actin-driven mechanisms in jellyfish oocytes that facilitate meiosis, suggesting ancient origins in metazoans.

This study identifies MYO1C as a regulator of rhodopsin trafficking and rod photoreceptor homeostasis, showing its cell-autonomous role in maintaining phototransduction recovery.

This study shows that substrate disorder promotes single-cell cancer invasion, comparable to cadherin loss, by altering invasion dynamics through spatial heterogeneity.

The paper identifies a stress-induced membrane insertion mechanism that activates the BepA metalloprotease by displacing its autoinhibitory plug, linking membrane association to protease function.

The paper identifies a conserved NADase domain, NIR, in bacterial immunity and eukaryotic proteins like human TEP1, linking bacterial defense mechanisms to eukaryotic functions.

This study identifies the structural basis of BRD4 interaction with P-TEFb and shows how BRD4 and AFF4 regulate P-TEFb activity through distinct mechanisms.

This study shows that NTHL1 loss increases mtDNA copy number and mitochondrial function, enhancing cellular resilience to oxidative stress through stress response pathways.

This study shows bacterial stimulation changes macrophage-derived extracellular vesicle lipid composition and identifies iNOS as an active inflammatory cargo in these vesicles.

This study identifies Myo6's role in DSB repair by interacting with KU70/80 and VCP, facilitated by F-actin, to extract the KU70/80 complex from chromatin.

This study identifies local mechanical heterogeneity as the driver of epidermal cell delamination through force balance changes and actomyosin remodeling in keratinocytes.

This paper identifies a β-strand complementation mechanism used by PilC/PilY1 proteins to license type IV filament assembly across diverse systems.

This study identifies Copine-6 as a protein that links calcium, phosphoinositide, and Rab11 signals to regulate glutamate receptor recycling in neurons.

This study identifies a conserved interaction between Bim1 and the Ndc80 complex in S. cerevisiae, showing it enhances microtubule attachment strength and is regulated by phosphorylation.

The paper demonstrates a method to multiplex FLIM using small molecule probes modified with bioorthogonal chemistry to achieve distinct fluorescent lifetimes without transfection.

The paper investigates how sustained photoprotection in plants involves enhanced fluorescence intermittency in a subpopulation of LHCII trimers associated with long-lived NPQ.

This study uses NMR to show phosphorylation alters the structure and interactions of the Ycf1p R region, affecting ATPase activity and NBD interactions in ABC transporters.