Stefano Freddi

The paper identifies a RAC1-PLCγ2 axis that decodes EGFR ligand bias by linking receptor trafficking to metabolic programs supporting cell migration.

This study shows that NUMB's Ex3 exon directs it to the plasma membrane, forming a complex with SNX9 that recruits and transports p53 via exosomes, enabling p53-dependent transcriptional activity in recipient cells.

This study identifies GL-Lect driven endocytosis as a driver of metastatic plasticity in breast cancer and shows pharmacologic inhibition can suppress invasive phenotypes.

The paper identifies the CRL7FBXW8 complex as an E3 ligase responsible for NUMB hyper-degradation in breast cancer, showing its inhibition rescues transformation phenotypes.

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

This study identifies Numb loss as a driver of aggressive bladder cancer through hyperactivation of the RhoA/ROCK/YAP signaling pathway, proposing a 27-gene signature for clinical stratification.

The paper shows that EGFR signaling via non-clathrin endocytosis requires a tripartite organelle platform linking Ca2+ oscillations to mitochondrial metabolism and ATP production for actin remodeling and collective motility.