electrophysiology

HRV-GUI is a MATLAB tool for HRV analysis across human, rodent, and diabetic gastroparesis data, showing physiologically plausible results and validation across synthetic and clinical datasets.

This study identifies how PIP2 binding at an allosteric site inhibits human rod CNG channels by stabilizing non-conductive conformations.

This study shows that tau isoform balance regulates axon initial segment maturation, excitability, and transport, linking cytoskeletal organization to neuronal function.

The paper introduces a method to analyze physiological data with multiple non-independent observations, ensuring each subject is represented once and without distribution assumptions.

The paper correlates plant bioelectrical signals with ionic energy flow across different organs under stress using a multi-domain framework.

The paper develops and validates an open-source ecosystem for implantable brain-computer interfaces and adaptive neuromodulation, demonstrating its capabilities through preclinical and human studies.

This study tracks physiological and EEG changes in cynomolgus macaques after aerosol VEEV-IAB infection, showing rapid autonomic nervous system disruption and persistent EEG alterations without detectable viral persistence.

The paper introduces the Neural Impact Score (NIS) to evaluate drug effects on brain organoids across multiple biological categories, demonstrating its utility in cross-species drug benchmarking.

This paper develops a novel NeuroMPS platform to monitor neuronal network dynamics in 3D human iPSC-derived neurospheres with high electrophysiological resolution and multimodal analysis.

This study compares two axon models to assess how structural and electrophysiological differences affect deep brain stimulation outcomes.

This study investigates how the wedge domain of PIEZO1 contributes to its inactivation through structural and functional analyses.

The paper introduces hydroMEA, a 3D hydrogel-based microfluidic device that enables real-time electrophysiological measurements of myelinated nerve-on-chip systems using human iPSC-derived neurons and Schwann cells.

The paper presents a multichannel LI-TMS array capable of electronically steering electric fields for network-level neuromodulation, achieving cortical fields comparable to tES without scalp contact.

This study investigates how cholesterol and its analogs regulate the hHv1 proton channel by altering S4 segment conformation, identifying key residues and mechanisms involved.

The paper investigates the M899I variant in Nav1.7, showing it causes pore collapse, leading to loss of sodium currents and pain insensitivity.

This study shows that hair cell function declines with age in mice before hearing loss is detectable, challenging the idea that stereocilia are the most fragile part of sensory cells in aging.

The paper uses an optogenetic mouse model to show that bypassing natural retinal encoding leads to spatiotemporal reorganization in cortical representation of artificial vision.

The paper uses simulations to explain conflicting experimental results on ephaptic coupling in cardiomyocytes by analyzing geometric configurations.

This study identifies an ER retention motif in hERG1b that enforces a fixed 2:2 stoichiometry in hERG1a/1b channels, with disruption leading to random subunit composition.

This paper develops a stochastic neural mass model to simulate cortical beta bursts in Parkinson's disease, showing that reduced background drive and enhanced synaptic coupling can reproduce and counteract altered burst dynamics.

This study uses optogenetics to control cAMP and HCN channels in cardiac and Parkinson's disease models, showing effects on heart rate and motor function.

vascr provides an R-based toolkit for streamlined analysis of cellular impedance sensing data, enabling rapid and robust interpretation of biological effects on cellular processes.

This study shows that mice and artificial neural networks reuse modular neuronal subspaces to perform complex cognitive tasks.

The paper introduces a new voltage indicator to image sub-millivolt membrane potentials and discovers bioelectric contact inhibition mediated by gap junctions.

This study examines how protamine interacts with OmpF at the single-molecule level, showing voltage and concentration-dependent current blockages and peptide length effects on binding.

This study shows that electrochemical deformation of PEDOT:PSS activates mechanosensitive pathways in HEK293T cells, revealing a mechanical component in conducting polymer-based interfaces.

This study shows that the first 43 amino acids of IRAG are sufficient to potentiate HCN4 channels, requiring contributions from HCN4's N-terminus and cAMP transduction center.

This study develops and applies methodologies to manipulate cardiomyocyte physiology in vitro and in vivo, revealing effects of optogenetic and chemogenetic tools on heart rate and calcium dynamics.

The paper demonstrates subthreshold asynchronous computations in biophysically detailed neuron networks using graded synaptic transmission without spiking.