host-pathogen & immune response

The paper examines how daily light exposure differs between extreme chronotypes and finds that these differences persist even when aligned to habitual sleep timing, with notable variations in exposure timing relative to sleep patterns.

This study shows that deleting Stim1/Stim2 in microglia reduces calcium signaling but leads to larger infarct sizes after ischemic stroke, suggesting CRAC signaling protects brain tissue.

This study shows that a co-culture of Delftia P1 and Microbacterium lacus efficiently removes paracetamol and its toxic metabolite 4-AP by coupling their degradation pathways.

This study identifies the CAV3-NCX1 axis as a mediator of ultrasound-induced inhibition of pathological brain hyperactivity, showing its role in suppressing hyperactive neurons and astrocytes.

The paper develops an individual-level host competence index linked to reproduction numbers and applies it to simulate transmission dynamics in four disease systems.

The paper identifies EveD, a rhizobial protein in EVs that affects nodule competitiveness and genotype-specific symbiotic responses in legumes.

This study identifies a reversible conformational switch in CdaR's YbbR domains that senses extracellular pH and regulates c-di-AMP signaling in Gram-positive bacteria.

This study develops a bivalent vaccine approach using BTV VP2 antigens and finds that co-expression of VP2 proteins interferes with neutralizing antibody induction, while monovalent vaccines provide effective protection.

This study shows that blocking CR2/CD21 on both B cells and follicular dendritic cells reduces GC activity and autoimmunity in lupus by synergistically inhibiting B cell responses and reshaping immunological memory.

This study shows dietary HSP90 extends C. elegans lifespan and healthspan via extracellular signaling, and combines it with a senolytic inhibitor for enhanced longevity.

This study develops a task to measure both intrinsic and extrinsic motivation and finds that drugs affect these motivations differently, highlighting pharmacological divergence.

This study shows that phosphorylation at Y674 in the SARS-CoV-2 spike S1/S2 loop affects spike processing and protease usage, impacting viral replication and pathogenesis.

This study compares the immunomodulatory effects of QS-21 and QS-7 in THP-1 macrophages, showing QS-7 enhances QS-21's activation while modulating inflammatory pathways.

RAMP-Seq co-amplifies full-length 16S rRNA and antimicrobial resistance genes in a single PCR, enabling integrated taxonomic and resistance profiling across diverse samples.

This study develops multi-specific nanobody-Fc fusions targeting TcdB that neutralize diverse C. difficile strains and improve infection outcomes in mice.

This study develops multivalent mRNA vaccines against tuberculosis using antigens identified in zebrafish, showing protection in mice, guinea pigs, and comparable efficacy to BCG.

This study investigates how genetic diversity and multiplicity of infection in Plasmodium species affect Anopheles coluzzii infectivity in Cameroon, finding that higher diversity and mixed infections increase mosquito infectivity.

This study shows that L-selectin shedding regulates neutrophil mobilization after heart attack but does not affect heart damage or remodeling.

This study shows that RSA during slow-paced breathing correlates with generalized anxiety symptoms beyond resting RSA and interoceptive measures in young adults.

This study shows that dopamine neurons in monkeys encode effort cost as negative reward value, contrasting with the positive reward prediction error signal.

This study shows that HRV biofeedback changes neural activity but not subjective anxiety during a brief breathing exercise.

The paper tests Darwin and Wallace's hypotheses on sexual dichromatism in birds using iridescent coloration data, finding support for both but stronger evidence for Darwin's hypothesis.

This study evaluates TACK compounds Pyr01 and Pyr02 for their ability to selectively eliminate HIV-1-infected macrophages, finding Pyr01 effectively targets infected cells while sparing uninfected ones.

The paper examines how thermal similarity within bird genera affects the strength of Bergmann's rule, finding that higher thermal similarity correlates with weaker body size temperature relationships.

This paper characterizes gp28, a phage-encoded cationic peptide that disrupts bacterial membranes and has broad bacteriostatic activity against Gram-negative and Gram-positive bacteria.

This study shows that maternal high-fat diet during gestation and lactation leads to systemic inflammation and altered gut-brain axis function in male offspring through disrupted tight junctions and reduced satiety peptides.

This study identifies capsule-permeable protein antigens against bacterial sepsis using a novel platform called L-VAC, showing broad cross-serotype protection through immunization.

The paper shows that mice learn to approach trimethylamine (TMA) through developmental exposure, contrasting with the innate aversion seen in related species.

This study identifies FraA and Ebp pili as key adhesion factors enabling Enterococcus faecalis to maintain attachment under fluid flow, with implications for preventing medical-device colonization.

This study shows that TSHZ3 deletion in cholinergic neurons impairs striatal cholinergic modulation, leading to repetitive behaviors in ASD, and that donepezil treatment reduces these behaviors.