D. Zhu

Mechanical evolution of metastatic cancer cells in three-dimensional microenvironment

This study uses optical Brillouin microscopy to analyze mechanical features of cancer spheroids over time, showing improved classification accuracy using these features.

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

Multi-omics reveals AKR1B1-regulated galactose metabolic as a driver of gastrointestinal stromal tumor progression

This study identifies AKR1B1-regulated galactose metabolism as a driver of gastrointestinal stromal tumor progression through multi-omics analysis.

Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states

This study identifies a PPARγ ligand series that shifts the receptor's conformational ensemble between active and repressive states, revealing how subtle chemical changes influence its function.

CCT3 drives Sorafenib resistance by inhibiting TFRC-mediated iron uptake in HCC

This study identifies CCT3 as a driver of Sorafenib resistance in HCC by inhibiting TFRC-mediated iron uptake, leading to ferroptosis resistance.

Deciphering fitness trade-offs in metabolite exchange at the origin of a bacterial cross-feeding community

The paper uses computational models to show that optimal metabolite exchange intensities in bacterial cross-feeding communities depend on glucose availability and shared metabolite access, enhancing community fitness.

Prokaryotic microbial diversity analysis and metabolic function prediction of salt lakes on the Qinghai-Tibet Plateau

This study analyzes microbial diversity and metabolic functions in two salt lakes on the Qinghai-Tibet Plateau using metagenomics, revealing differences in microbial composition and salinity adaptation strategies.

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

56Fe ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice

This study shows that 56Fe ion exposure increases lung and brain tumor incidence similarly in male and female mice, with 56Fe ions causing faster tumor development than X-rays.

Optimizing Cell Therapy by Sorting Cells with High Extracellular Vesicle Secretion

The paper develops a method to enrich cells with high extracellular vesicle secretion and shows improved therapeutic outcomes in a mouse model.

Nature-based solutions in Australia: a systematic quantitative literature review of terms, application and policy relevance

This paper reviews Australian literature on nature-based solutions, finding inconsistent definitions, urban focus, and lack of policy integration, and recommends standardization and collaboration.

Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion Loop

This study engineers DENV variants with mutated fusion loops that evade neutralizing antibodies but retain sensitivity to cross-reactive antibodies, offering tools for vaccine development.

T cell development is regulated by high fidelity replication of mitochondrial DNA

This study shows that high fidelity mitochondrial DNA replication is essential for normal T cell development in the thymus, as reduced fidelity leads to premature thymocyte decline.

Control of Clostridiodes difficile virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motility

This study investigates the role of the FliC-FliW-CsrA network in C. difficile virulence and physiology, showing that these proteins regulate toxin production and metabolism even in non-motile strains.

Proteomics Characteristics Reveal the Risk of T1 Colorectal Cancer Metastasis to Lymph Nodes

The paper develops a proteomics-based classifier to predict lymph node metastasis in T1 colorectal cancer using protein expression patterns and machine learning.

Re-emergence of Severe Acute Diarrhea Syndrome Coronavirus (SADS-CoV) in Guangxi, China, 2021

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerations

This study identifies CFAP418's role in lipid binding and membrane processes, showing that its disruption causes lipid imbalance and mitochondrial defects in retinal degenerations.

Long non coding RNA L13Rik promotes high glucose-induced mesangial cell injury by regulating miR-2861/CDKN1B axis

This study identifies L13Rik as a lncRNA that promotes mesangial cell injury in diabetic nephropathy by regulating the miR-2861/CDKN1B axis.

Spinning Disk Multifocal Microscopy for Dynamic Arbitrarily Shaped Surface Imaging at Centimetre Scale and Micrometre Resolution

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy

This paper develops a machine learning method to design more effective AAV libraries with better packaging capabilities and diversity, achieving higher success rates in gene therapy applications.

Trait-based mechanistic approach highlights global patterns and losses of herbivore biomass functional diversity

The paper develops a mechanistic model of global herbivore biomass using functional traits and vegetation data, revealing significant declines in large herbivore biomass due to human activity.

Progressive chromatin silencing of ABA biosynthesis gene permits seed germination in Arabidopsis

The paper shows that RZ-1 and PRC2 work together to silence NCED6, a gene involved in ABA biosynthesis, which is essential for seed germination in Arabidopsis.

Ultrafast, one-step, and microwave heating-based synthesis of DNA/RNA-AuNP conjugates

This paper develops a microwave heating-based method to rapidly synthesize DNA/RNA-AuNP conjugates with high stability and broad applicability.

Effect of charge on protein preferred orientation at the air-water interface in cryo-electron microscopy

This study investigates how detergent charge affects protein orientation at the air-water interface in cryo-EM, finding that anionic detergents modify the interface charge to improve protein orientation distribution.

FliW and CsrA govern flagellin (FliC) synthesis and play pleiotropic roles in virulence and physiology of Clostridioides difficile R20291

This study shows that FliW and CsrA regulate flagellin (FliC) synthesis in C. difficile R20291, affecting virulence and physiology through a mechanism similar to the 'FliW-CsrA-Hag' switch in B. subtilis.

ZFP207 controls pluripotency by multiple post-transcriptional mechanisms

This study identifies ZFP207's role in maintaining mouse embryonic stem cell identity through post-transcriptional mechanisms, including alternative splicing and RNA-binding protein activity.

Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

Evaluation of exosome-encapsulated miR-23a/b in the diagnosis of human coronary heart diseases

This study evaluates serum exosomal miR-23a and miR-23b as biomarkers for diagnosing coronary heart diseases, finding miR-23a is downregulated and predictive of stable angina and AMI.

Cwl0971, a novel peptidoglycan hydrolase, plays pleiotropic roles in Clostridioides difficile R20291

This study identifies Cwl0971 as a peptidoglycan hydrolase in C. difficile that affects autolysis, toxin release, sporulation, and pathogenicity.