Schizophrenia research and treatment

This study examines the reward-complexity trade-off in schizophrenia patients and healthy controls, finding similar empirical trade-off curves but differing policy complexity and bias.

The paper identifies nine clinical phenotypes and polygenic risk scores associated with quality of life in schizophrenia patients and their relatives.

This study shows that vitamin B complex supplementation reduces behavioural and histomorphological impairments caused by maternal deprivation in rats.

This paper identifies a common genetic factor across schizophrenia, bipolar disorder, and major depressive disorder using a trans-diagnostic, top-down approach, and links it to ZNF391 expression patterns in the brain that correlate with cognitive and neuroimaging traits.

This study examines the neural correlates of visual backward masking in bipolar disorder patients, finding reduced global field power amplitudes similar to schizophrenia.

The paper investigates how age affects symptom expression in first-episode psychosis using longitudinal data, finding age-related changes in perceptual and non-perceptual positive symptoms.

The paper identifies global down-regulation of proteasome subunits in a subgroup of schizophrenia patients through transcriptome sequencing and pathway analysis across multiple cohorts.

This study shows that mTORC1 in the striatum prevents haloperidol-induced catalepsy, suggesting it could be a target for reducing antipsychotic side effects.

The paper examines how polygenic risk for psychiatric disorders and smoking behavior influence psychotic experiences in UK Biobank participants, finding independent and synergistic effects.

The paper maps individual deviations from normative brain structure in schizophrenia patients and finds high heterogeneity, with most patients showing infra-normal deviations in at least one region.

The paper identifies a subgroup of schizophrenia patients with extreme cognitive deficits by analyzing sulcal width dissimilarity using the PBSI-SW metric.

This study uses machine learning to predict the severity of specific psychotic symptoms from fMRI and behavioural data in schizophrenia patients.

The paper investigates whether damaging variants in SLC6A9, the gene for GlyT-1, are protective against schizophrenia by analyzing exome data from 4225 cases and 5834 controls.

The paper investigates how prior beliefs influence perception in early psychosis, finding differences in reliance on cognitive and perceptual priors between prodromal, psychotic, and control groups.

The paper investigates theta phase synchrony and N1 suppression in schizophrenia and clinical high-risk groups, finding theta inter-trial coherence suppression is more sensitive to corollary discharge abnormalities in early illness schizophrenia.

This study identifies genetic factors influencing antipsychotic-induced adverse reactions in mice using RIX lines, finding strong strain and treatment interactions for behavioral phenotypes.

The paper identifies altered calcium-binding proteins in the cerebellum of schizophrenia patients, linking them to synaptic dysfunction and suicide behaviors.

This study uses diffusion tensor imaging and machine learning to predict brain age in schizophrenia and bipolar disorder patients, finding age overestimation in both groups compared to controls.

This study shows that dopamine manipulation affects social inferences related to paranoia in healthy individuals, with haloperidol reducing harmful intent attributions and L-DOPA having context-dependent effects.

The paper validates associations between combinations of dopaminergic gene polymorphisms and schizophrenia risk in a matched case-control study.

The study investigates the association between dopamine D1 receptor availability and delusional ideation in healthy controls using PET and questionnaire data, finding little to no linear association.

This study investigates differences in auditory precision encoding connectivity between schizophrenia spectrum disorder patients, non-psychotic psychiatric inpatients, and healthy controls, finding group-specific and continuum-related connectivity changes.

This study examines brain volume changes in chronic schizophrenia patients and controls over 13 years, finding limited evidence of progressive brain volume loss beyond normal aging.

The paper evaluates rodent auditory biomarkers as translational markers for NMDAR dysfunction and supports SRKO mice as a model for PV interneuron dysfunction in schizophrenia.

This study examines how antipsychotic medication affects white matter microstructure in adolescents with early-onset psychosis using MRI and diffusion measures.

The paper examines feedforward parietal-prefrontal connectivity in schizophrenia patients and healthy controls, linking it to delusions and polygenic risk for schizophrenia.

The paper assesses reinforcement learning deficits in psychosis risk groups and finds they are not linked to schizophrenia polygenic risk in the general population.

The paper identifies lamina-specific gene expression changes in pyramidal neurons from schizophrenia patients compared to controls, highlighting immune and synaptic pathway disruptions.

The paper investigates associations between polygenic risk scores for schizophrenia, psychotic-like experiences, and structural brain network properties in healthy UK Biobank participants.

The paper investigates how diagnosis and symptom domains affect cognitive performance in a case-control study of severe mental illness, finding distinct cognitive profiles linked to specific symptom domains.