Neurotransmitter Receptor Influence on Behavior

This study shows that social housing reduces methamphetamine self-administration in female rats but not males, with male self-administration influenced by dominance status.

The paper shows that dopamine neurons in monkeys encode subjective reward value by integrating utility and subjectively weighted probability, aligning with observed choice behavior.

The paper identifies a striatal circuit that encodes reward distributional information, showing D1 and D2 MSNs encode different reward distribution tails.

This study reviews and analyzes 23 experiments to assess if chronic unpredictable stress increases intracranial self-stimulation thresholds in rats, finding no significant increase and no correlation with sweet preference.

This study shows that early life stress impairs VTA coordination of BLA network and behavioral states by weakening dopamine signaling between VTA and BLA, leading to increased social avoidance.

This paper identifies a dopamine pathway that enables flavour-nutrient learning by integrating interoceptive signals from the mouth and gut.

This study shows that GPER-1 activation in the DLS reduces male but not female preference for saccharin, while systemic GPER-1 activation reduces cocaine preference in both sexes.

This study investigates the role of NAc D2-expressing neurons in reward processing using optogenetic stimulation, finding that activation has rewarding effects but disrupts licking behavior, while inhibition induces a negative hedonic state.

This study introduces a new behavioral task to assess compulsive-like cocaine seeking in rats and shows it emerges after extended access with punishment.

This study shows that early postnatal fluoxetine exposure alters adult prefrontal cortex circuits via 5-HT7 receptors, affecting neuronal firing patterns and contributing to depressive and anxiety-like behaviors.

This study identifies dopamine's role in devaluing reward memories through experimental and computational methods, showing its necessity for mediated devaluation and hedonic evaluation reduction.

This study shows that deleting MORs in Foxp2-expressing neurons reduces aversion-resistant alcohol drinking and related behaviors in mice.

This study characterizes molecular changes in the ventral striatum of individuals with cocaine use disorder using multi-omics and single-cell approaches, identifying perturbations in metabolic pathways and cell-type-specific alterations.

This study identifies distinct VTA GABA neurons that regulate force vectors during motivated behavior through precise force tuning and optogenetic manipulation.

This study examines operant ethanol self-administration in female rats, identifying distinct phenotypes and withdrawal-induced intake escalation similar to males.

The paper tracks and manipulates striatal neuron activity during goal-directed learning and habit formation, finding D1+ neurons maintain stable action representations while A2A+ neurons show transient or slow reorganization.

This paper develops a tool to analyze fine-grained behavior in depression-like tests and finds that cognitive processes differ between the forced swim and tail suspension tests.

This study examines if alcohol vapor exposure affects individual differences in punished alcohol self-administration in rats, finding no significant effect.

This study shows that disrupting or inhibiting carbonic anhydrase 4 reduces synaptic and behavioral adaptations during oxycodone withdrawal in mice.

This study examines sex differences in ethanol consumption and its regulation by glutamate AMPA receptors in C57BL/6J mice, finding higher ethanol intake and reinforcement in females.

This study shows that deleting Ox1R in dopaminergic neurons increases novelty-induced locomotion and exploration without affecting other behaviors.

This study maps the anatomical connections and activation patterns of the dorsomedial nucleus accumbens (dmACB) and finds reduced dmACB activation correlates with increased opioid seeking after abstinence.

This study uses a non-linear clustering approach in rats to identify distinct behavioral and neuronal profiles associated with heroin vulnerability and resiliency, reflecting human opioid use disorder heterogeneity.

This study shows that Fusobacterium nucleatum enhances amphetamine-induced behaviors through butyrate release and HDAC1 inhibition, increasing dopamine release.

The paper investigates how tonic activity patterns affect dopamine release in striatal brain slices, finding that tonic stimulation alters DA release kinetics to resemble in vivo conditions.

This study shows that BDNF in vlOFC-to-DLS neurons reduces alcohol intake by decreasing habitual seeking, but not sucrose intake.

The paper shows that policy complexity suppresses dopamine responses to reward outcomes, reducing behavioral sensitivity to these outcomes.

This paper conducts a meta-analysis of dopamine and serotonin pharmacological manipulations in humans, finding distinct associations with reward and punishment reinforcement learning components.

This study identifies a mid-insula to BNST neural circuit that drives stress susceptibility and negative affect during abstinence in female mice, suggesting it as a therapeutic target for AUD.