Neurotransmitter Receptor Influence on Behavior

The paper identifies Rab3b as a gene influencing cocaine response and habituation in mice through integrative genomic analysis of multiple studies.

This paper models dopamine's role in learning and action inference by linking prediction errors to reward and habit formation in the basal ganglia.

This study shows that anterior insular cortex lesions after heroin exposure increase loss of control and relapse, contrasting with cocaine findings.

This study shows chronic serotonergic drugs reduce dopaminergic neurons in the VTA and correlate with reduced anticipatory freezing behavior in a rat model of fear.

This study identifies a dopamine-induced gene expression signature in the nucleus accumbens that drives cocaine-induced physiological and behavioral adaptations in rats.

This study shows ceftriaxone reduces cocaine relapse and NA core glutamate efflux in rats during context+cue relapse tests by decreasing activity in prelimbic cortex projections to the NA core.

The paper investigates how putative dopamine neurons in rats respond to discriminative stimuli in a task involving occasion setting, finding heterogeneous single-unit responses rather than population-level changes.

The paper investigates how dopamine transporter blockade affects reward-seeking behavior in rats using optical stimulation, finding differential effects that suggest parallel reward pathways.

This study identifies estrogen receptor α's role in enhancing ethanol excitation of VTA dopamine neurons and binge drinking in female mice, highlighting sex-specific mechanisms in alcohol use disorder.

The paper identifies novel COMT inhibitors that improve cognitive flexibility in rats by modulating dopamine metabolites in the frontal cortex and cerebrospinal fluid.

The paper identifies brain regional gene expression networks affected by chronic ethanol exposure and consumption in mice, finding unique patterns in prefrontal cortex and nucleus accumbens.

This study compares dopamine release, uptake, and D2 autoreceptor function across different striatal regions in adolescent and adult rats, finding decreased dopamine release in the nucleus accumbens core in adolescents.

This study shows that VTA dopamine neurons bidirectionally control impulse vector and anticipatory behavior during motivated actions.

This study investigates sex-specific neuroadaptations in somatostatin neurons during forced abstinence from alcohol, revealing altered intrinsic excitability and cFos expression in specific brain regions.

This study shows dopamine modulates decision-making during foraging by influencing background reward rates rather than foreground rewards.

The paper develops a framework to model how motivation affects choice and learning in the basal ganglia by integrating physiological states with reinforcement learning mechanisms.

This study shows that peripherally administered oxytocin reduces methamphetamine self-administration and seeking in rats, but this effect requires vagus nerve signaling, with partial sex differences observed.

This study shows that ketamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in mice, suggesting it may interfere with memory of morphine-context associations rather than just alleviating negative affective states.

This study investigates how bidirectional pharmacological perturbations of the noradrenergic system affect tactile detection in mice, finding distinct behavioral impacts from localized versus systemic treatments.

This study identifies the cAMP-Fyn signaling pathway in dorsomedial striatum direct pathway neurons as a driver of excessive alcohol consumption in mice.

The paper identifies 5' UTR variants in Hnrnph1 that reduce 5' UTR usage and hnRNP H protein levels, linking these changes to reduced methamphetamine sensitivity.

This study shows that adolescent-onset methamphetamine self-administration in rats leads to increased drug intake and deficits in object-in-place recognition memory, with no changes in receptor expression.

This study shows ceftriaxone reduces cocaine-seeking by interacting with mGlu2/3 receptors in the nucleus accumbens core, as blocking these receptors prevents ceftriaxone's effect.

This study shows that M1 receptor agonist VU0364572 prevents and reverses cocaine addiction-related behaviors in rats, with lasting effects on dopamine and glutamate signaling.

This study investigates the roles of striatonigral and striatopallidal pathways in action performance and timing using optogenetic stimulation in mice.

This study investigates how serotonin and dopamine depletion affects social learning by examining behavioral and neural responses in healthy volunteers using fMRI.

This study shows acute stress enhances appetitive learning by increasing dopamine release in the ventral lateral striatum, which is blocked by dopamine receptor antagonists.

The paper investigates whether maternal immune activation in rats increases vulnerability to cocaine-related behaviors in offspring, finding no differences in cocaine reward or extinction but identifying potential biomarkers for schizophrenia.

This study identifies midbrain cholinergic neurons as a major source of acetylcholine in the striatum, showing their role in modulating striatal circuits and action control.

This study compares noradrenergic and dopaminergic neuron activity in monkeys during task performance, finding that noradrenergic neurons predict re-engagement after failure and respond to task state changes.