This study investigates the role of Hnrnph1 in fentanyl-induced behaviors, finding reduced sensitivity and reward in mutants with sex-specific effects.

2 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceThe FASEB JournalPeer-reviewedMay 13, 2020

5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity

Qiu T. Ruan, Neema Yazdani, Eric R. Reed…·Camron D. Bryant

The paper identifies 5' UTR variants in Hnrnph1 that reduce 5' UTR usage and hnRNP H protein levels, linking these changes to reduced methamphetamine sensitivity.

13 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeuroscienceJournal of NeurosciencePeer-reviewedNov 8, 2019

A mutation in Hnrnph1 that decreases methamphetamine-induced reinforcement, reward, and dopamine release and increases synaptosomal hnRNP H and mitochondrial proteins

Qiu T. Ruan, Neema Yazdani, Benjamin C. Blum…·Camron D. Bryant

This study identifies a mutation in Hnrnph1 that reduces methamphetamine-induced reinforcement, reward, and dopamine release while increasing synaptic hnRNP H and mitochondrial proteins in mice.

44 citations

mouseproteomics

𝕏 PostBluesky

NeuroscienceNeuroscience LettersPeer-reviewedJul 9, 2018

Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation

Qiu T. Ruan, Neema Yazdani, Jacob A. Beierle…·Camron D. Bryant

The paper examines changes in hnRNP H localization in primary rat cortical neurons after D1 dopamine receptor activation, finding increased nuclear immunostaining of the C-terminal domain without changes in protein levels.

9 citations

ratprotein structure

𝕏 PostBluesky