Smoking Behavior and Cessation

This study demonstrates vaping-induced pulmonary injury in mice using a JUUL pen inhalation model, showing structural and transcriptional changes linked to respiratory distress.

The paper identifies individual differences in nicotine seeking motives in rats and shows varying responses to varenicline during nicotine withdrawal.

The paper analyzes smoking and sex effects on gene expression across multiple tissues using public data, identifying tissue-specific and sex-related gene expression changes.

This paper investigates heterogeneous genetic effects on smoking behaviors using UK Biobank data, finding evidence of sex- and psychiatric disorder-specific genetic associations and improved polygenic risk score prediction with sex-specific effects.

This study examines genetic overlap and causal links between smoking behaviors and psychiatric traits in adolescents and adults, finding significant genetic correlations and causal associations.

The paper examines how genetic predisposition and insurance status interact to influence smoking behavior after a health shock, finding that genetic factors affect the response to insurance coverage.

The paper evaluates vertical and horizontal pleiotropy pathways linking genetic variants, white matter integrity, and nicotine dependence using UK Biobank data.

This study shows that both daily and intermittent smoking reduce glutamate and other metabolite concentrations and gray matter volume in the prefrontal cortex, with no difference between smoking types.

The paper identifies novel genetic loci associated with nicotine dependence and shows genetic correlations with other smoking traits and comorbidities using genome-wide association studies.

The paper replicates main effects of rs16969968 and age of smoking onset on smoking quantity but fails to replicate their interaction effect.

This paper develops an MRI-compatible nasal delivery system for nicotine to study addiction dynamics and confirms its ability to elicit craving cycles and activate addiction-related brain circuits.

The paper identifies Slit3 as a genetic locus influencing nicotine preference in zebrafish and smoking behavior in humans through mutagenesis screens and SNP analysis.

This study examines how nicotine dependence and acute nicotine stimulation affect attention and cognitive control using fMRI during Go-Nogo and Flanker tasks, finding modulations in attention but not cognitive control.

The paper assesses the association of two gene sets with smoking behaviors using GWAS data and finds they contribute little to the heritability of these traits.

This study examines how different nicotine concentrations in e-cigarette vapor affect blood nicotine and cotinine levels and withdrawal signs in rats over time.

The paper investigates how CHRNA5-A3-B4 gene variants affect smoking behaviors and nicotine responses in humans, finding reduced cravings and smoke inhalation in minor allele carriers.

This study dissociates habenula activity linked with nicotine withdrawal from striatal activity linked with addiction severity using pharmacological fMRI.

Vaping nicotine-containing e-cigarettes causes addiction-like behaviors and cardiopulmonary issues in rats, which are reduced by varenicline.

The paper examines how childhood socioeconomic status interacts with genetic risk to influence peak cigarette consumption in adulthood.

This study uses electronic cigarettes with fMRI to examine brain activation during smoking, revealing neural networks and deactivations associated with simulated smoking.

This study tests if tobacco abstinence decreases reward sensitivity in humans using objective and subjective measures, finding small decreases in self-report measures but no change in behavioral measures.

The paper develops and validates a 58-item survey (REI) measuring reward sensitivity in smokers, finding it reliable but with modest predictive validity.