Neuroscience and Neuropharmacology Research

The paper proposes a framework to identify the presence of a series-connected replacement pool in synaptic vesicle dynamics using electrophysiological methods.

The paper describes a method to selectively activate mossy cells (MCs) in hippocampal slices using optogenetics and shows that MC input to granule cells (GCs) is weak but widespread.

This study identifies rapid brain-wide synaptic remodeling in hyperacute stroke, showing structural and functional changes in the ischemic core, penumbra, and contralateral cortex.

The paper introduces optomapping, a fast 2-photon optogenetic method validated by paired recordings, to study excitatory microcircuit organization in mouse V1, revealing log-normal synaptic strength distributions, layer-specific connectivity, and novel short-term plasticity patterns.

The paper uses proteometric imaging to classify synapses by glutamate receptor subunits, finding subclasses linked to synaptic plasticity and dendritic coupling.

The paper shows that excitatory synapses on Purkinje cells develop through a stepwise molecular process involving initial common proteins and later input-specific proteins.

The paper identifies two molecularly distinct subtypes of sympathetic preganglionic neurons in mice that selectively regulate gastrointestinal and adrenal functions through non-overlapping innervation patterns.

This study investigates plateau potentials in rat prefrontal cortex layer 2/3 pyramidal neurons, showing they can occur independently of distal apical dendrites through TRP channel-mediated calcium influx.

This study shows that Stem Cell Factor enhances inhibition of Purkinje Cells via presynaptic Kit, leading to long-term suppression of firing and specific potentiation of basket cells.

The paper investigates how a subset of mouse hippocampus CA1 pyramidal neurons selectively learn sparse synaptic input patterns through optogenetic stimulation and postsynaptic depolarization.

The paper investigates whether GABA and astrocytes mediate the modulation of spinal sensory input by peripheral nerve stimulation, finding that GABAergic astrocytes increase afferent fibre excitability.

This study shows that prolonged visual deprivation in adult mice induces reversible, non-homeostatic plasticity at thalamocortical synapses in layer 4 pyramidal neurons.

The paper measures extracellular chloride concentrations in the brain and finds they are lower and more variable than previously thought due to displacement by immobile anions, affecting GABAA receptor function.

This study identifies α2δ1 as an extracellular GluA1 interactor that regulates LTP, spatial memory, and seizure susceptibility through its role in AMPAR trafficking.

The paper shows that expressing a synaptopodin construct in non-neuronal cells generates ER stacks resembling the spine apparatus, revealing a role for synaptopodin-dependent actin matrix in their formation.

The paper demonstrates a new form of associative plasticity between ascending axon and parallel fibre synapses on Purkinje cells, showing that synchronous stimulation of these inputs triggers long term potentiation at ascending axon synapses.

The paper investigates how spinal microcircuits adapt in a mouse model of motoneuron degeneration, finding specific multiphasic homeostatic compensations that preserve force output.

The paper investigates how dopamine and astrocytic calcium activity coordinate during behavioral breaks in mice, showing dopamine drives astrocytic activity and affects learning.

The paper shows that in vivo modulation of network activity changes the nanoscale organization of axo-axonic synapses, reducing Gephyrin SSD volume and weakening synaptic contacts.

This study shows that loss of GPT2 in mice disrupts glutamate metabolism and synaptic transmission, with rescue by alpha-ketoglutarate supplementation.

This study identifies HDAC4 as an inhibitor of neurogranin expression, regulated by NMDA receptor activity and transcription factors like REST and MEF2.

This study shows lactate enhances NMDA receptor currents through redox-sensitive cysteines in GluN2B and CaMKII interactions, linking astrocyte metabolism to synaptic plasticity.

This paper introduces a PU learning-based method for detecting and segmenting miniature synaptic calcium transients, showing improved performance over traditional methods in cultured rat neurons.

The paper shows that D1R/NMDAR heteromers regulate protein translation in NAc MSNs, with excitatory transmission increasing translation and D1R antagonism reversing this effect.

The paper reveals that striatal astrocytes rapidly modulate cholinergic interneurons and dopamine release through subsecond calcium dynamics in mice and humans.

The paper identifies subtype-specific plasticity in SST neurons during sensory learning and develops a classifier to predict learning-associated response plasticity.

This study investigates transcriptional and physiological changes in thalamocortical connections after unilateral whisker denervation, finding increased synaptic activity and gene expression related to glutamate receptors.

The paper introduces a method called patch-walking to improve the efficiency of finding synaptic connections by reusing a single patch clamp electrode, resulting in more connections probed per experiment.