Eric M. Morrow

This study uses single-cell RNA sequencing in a CS rat model to identify dynamic neurodegenerative mechanisms, revealing early mitochondrial dysfunction and microglial activation overlapping with Alzheimer's disease.

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.

This study shows that loss of GPT2 in mice disrupts glutamate metabolism and synaptic transmission, with rescue by alpha-ketoglutarate supplementation.

This study identifies GGA1 as an interacting partner of NHE6, showing that their interaction is critical for NHE6 localization to endosomes.

This paper corrects a pathogenic mutation in iPSCs from a Christianson syndrome patient using CRISPR/Cas9, resulting in functional NHE6 protein expression.

The paper uses iPSC-derived neurons from Christianson syndrome patients to show allele-specific responses to rescue strategies, highlighting the need for personalized therapeutic approaches.

This study identifies 99 genes associated with autism spectrum disorder through large-scale exome sequencing, showing differences in mutation frequencies between ASD and severe neurodevelopmental delay groups.