Alzheimer's disease research and treatments

This paper introduces a Rheo-NMR platform to analyze amyloid formation kinetics in real-time and provides insights into environment-dependent aggregation pathways.

This study uses proximity labeling to compare the interactomes of pyroglutamate-modified and unmodified amyloid beta in AD and control hippocampus, identifying unique and shared protein interactions.

This paper develops a detergent-free method to produce Aβ42 oligomers compatible with solid-state NMR and shows they induce stronger microglial inflammation than monomers.

The paper demonstrates a non-invasive nasal swab platform with single-cell Western blotting for Alzheimer's disease biomarker detection, showing superior diagnostic performance compared to blood-based methods.

The paper identifies genetic variants associated with AD-related plasma biomarkers in the Amish cohort using GWAS and linkage analysis.

This paper identifies and optimizes a molecular glue that stabilizes the NOS1AP-SCRIB interaction, showing therapeutic effects in Alzheimer's patient-derived neurons.

The paper analyzes bulk RNA-seq data from multiple auditory regions in 5xFAD mice across ages to identify spatiotemporal gene expression changes associated with AD progression.

This study shows intranasal insulin does not reduce brain amyloid plaques in 5xFAD mice but changes intestinal morphology and fecal metaproteomics.

This study shows tau forms multilayered condensates on microtubules via a prewetting-like transition, creating a selective microenvironment that restricts some proteins while recruiting others.

This study examines depth-dependent changes in cerebral oxygenation in Alzheimer's disease models, finding that tau disrupts oxygen levels and that neuronal loss is not due to local hypoxia.

The paper uses single-cell transcriptomics and phenotypic analysis of gene knockouts in hiPSC-derived neurons and astrocytes to identify cell-type specific and shared mechanisms of Alzheimer's disease risk genes.

This study evaluates the effects of Hericium erinaceus and donepezil on amyloid accumulation and autophagy in Aβ1-42-induced N2a cells, finding synergistic effects on cell viability and protein expression.

This study shows that carbonic anhydrase inhibitors improve heart function in Alzheimer's mice by reducing amyloid-β and restoring neurotrophic signaling.

The paper identifies sequence changes that bias tau aggregation toward CTE-like structures using mutagenesis and structural analysis.

The paper develops a spatial multi-omic method to study lipid dysregulation in Alzheimer's disease across brain regions in mice, identifying region-specific glial metabolic changes.

This study shows that an engineered bacterium worsens neurodegeneration in a tauopathy mouse model by altering immune responses, while the unmodified strain has no effect.

The paper identifies stage-specific synaptic proteomic signatures in Alzheimer's disease and links them to plasma proteins associated with disease progression and cognitive decline.

This study identifies A. muciniphila's neuroprotective effects against Cd-induced hippocampal dysfunction through restoration of post-transcriptional RNA regulation and splicing patterns.

CAPTOR-1, a small molecule inhibitor of NOS1AP-tau interaction, reduces tau pathology and improves cognition in AD models.

This study uses NMR-metabolomics to show CHF6467 mitigates Aβ(1-42)-induced metabolic changes in SH-SY5Y cells by promoting phospholipid precursors, reducing glutamate excitotoxicity, and restoring energy metabolism.

This study shows that the MAPT P301L mutation causes neuronal network hyperexcitability through subtype-specific tau pathology and altered synaptic transmission.

The paper investigates delayed glucose metabolism changes in APP/PS1 KI mice after closed-head injury, finding increased pyruvate and lactate labeling in cortex and hippocampus 8 months post-injury.

This study examines how early-life handling and sex influence cognitive resilience and pathology in APP/PS1 mice over time, finding improved memory and reduced pathology in handled mice and better cognition in females despite greater pathology.

Cortical organoids from healthy human iPSCs, seeded with Alzheimer brain tau, form three-repeat tau filaments that cryo-EM shows are identical to Alzheimer paired helical filaments and need endogenous tau.

This paper models how a magnetic field enhances DHA delivery to increase acetylcholine levels in Alzheimer's disease, showing significant time reduction for therapeutic effects.

This study shows that primary neurons can propagate Alzheimer's disease paired helical filaments and that tau filament folds determine inclusion morphologies.

This study uses proteomic analysis in aged rhesus macaques to show that GCPII inhibition alters region-specific protein expression patterns linked to Alzheimer's disease pathology.

This study uses experimental and molecular dynamics methods to show that Aβ40 and Aβ42 have distinct co-assembly pathways with lipids, with lipid effects varying by isoform and lipid composition.

This study compares endogenous viral elements in Alzheimer's Disease patients and cognitively healthy centenarians using long-read sequencing, finding higher EVE burden in AD patients.