Malaria Research and Control

This study develops pantothenamide-mimics with thiazole rings to overcome degradation by pantetheinase, showing potent antiplasmodial activity and enzyme selectivity.

The paper determines the cryoEM structure of PfATP4, revealing a novel apicomplexan-specific binding partner, PfABP, which may guide the design of new inhibitors.

The paper uses explainable AI to distinguish between insecticide-resistant and susceptible Anopheles gambiae strains based on flight trajectory analysis.

This study evaluates the efficacy of the BiteBarrier transfluthrin emanator against various malaria and arbovirus vectors in semi-field settings, showing high protection and mortality rates across different mosquito species and resistance statuses.

This study identifies the localization and functions of two pyrophosphatases in Plasmodium falciparum, showing their roles in pyrophosphate homeostasis across subcellular compartments.

This study models how insecticide decay affects resistance evolution in monotherapies and mixtures, showing decayed insecticides can increase selection pressure and reduce the effectiveness of mixtures.

This study uses anti-gSG6-P1 antibody levels to assess Anopheles exposure seasonality and human behavior impacts on malaria risk in Sisaket Province.

The paper determines the structure of the Pfs230:Pfs48/45 complex bound to transmission-blocking antibodies, revealing molecular interactions and epitopes that inform vaccine development.

This paper develops a targeted genomic surveillance approach for insecticide resistance in malaria vectors, identifying resistance variants and demonstrating predictive modeling with high accuracy.

The paper shows that the 3D11 anti-CSP monoclonal antibody neutralizes Plasmodium berghei sporozoites in the liver after several hours, inhibiting motility and leading to parasite killing.

The paper develops DINEMITES, a statistical method to distinguish new from persistent infections using longitudinal genotyping data, showing improved accuracy over simple rules.

This study compares DNA replication dynamics in two Plasmodium species with different A/T-content genomes, finding that P. falciparum has slower and more consistent replication fork speeds despite high A/T bias.

The paper examines the population structure of DBLα types in Sub-Saharan Africa, finding varying conservation levels across geographical scales and frequencies.

This study identifies quinoxaline-based anti-schistosomal compounds with potent anti-malarial activity against Plasmodium falciparum, including resistance mechanisms involving pfqrp1 and pfatp2.

This study develops a TRIO VLP vaccine targeting Anopheles mosquito salivary protein to enhance immunity against Plasmodium, showing strong antibody responses but limited protective efficacy in a malaria challenge model.

This study identifies PfLPLAT1 as essential for Plasmodium falciparum cell cycle progression and cytostome function, with its deficiency causing developmental arrest and morphological changes.

The paper investigates Anopheles stephensi larval habitat productivity in Ethiopia, finding that superproductive sites dominate larval populations during dry seasons, suggesting targeted control could reduce their numbers.

This paper develops a new Plasmodium berghei parasite line with constitutive Cas9 and inducible Cre recombinase for conditional gene editing, demonstrating its use in knocking out the CLAMP gene.

This study models how seasonal weather affects mosquito population dynamics in different regions, showing that ignoring seasonality leads to inaccurate predictions of mosquito abundance and stage structure.

The paper identifies biases in estimating multiplication rates of pathogenic organisms due to developmental sampling and synchrony patterns, showing overestimation in diverse species.

The paper analyzes the population genetics of Anopheles funestus in Tanzania, identifying two distinct genetic populations with different resistance backgrounds and suggesting geographic barriers to gene flow.

This study compares mating behavior between Anopheles funestus and Anopheles arabiensis under controlled conditions, finding species-specific differences in copulation timing and light response.

The paper identifies proteins involved in cytoadherence of P. falciparum by genetically modifying 15 exported proteins and showing aberrant adhesion in three modified lines.

This study identifies PP1 phosphatase as a dual regulator of the malaria parasite's egress pathway, controlling cGMP homeostasis and vacuole rounding-up.

The paper identifies novel PfEMP1 variants associated with rosetting in Plasmodium falciparum, expanding the known types of PfEMP1 that mediate this phenotype.

This study identifies Casein Kinase 2 as the kinase responsible for phosphorylating VAR2CSA, enhancing its CSA binding and infected erythrocyte adhesion.

The paper models PfATP4 structure using homology and validates predictions through genetic manipulation, identifying key residues for function and resistance.

This study identifies the global release of translational repression in Plasmodium parasites during host-to-vector transmission using transcriptomics and proteomics.