Malaria Research and Control

This study shows AP2-L is essential for Plasmodium liver-stage development by regulating PVM formation and host-cell interactions.

The paper reports a case of human infection with an ape-like Plasmodium vivax parasite, identified through whole-genome sequencing, suggesting zoonotic transmission from wild gorillas and chimpanzees.

This study identifies new chemotypes that inhibit Plasmodium falciparum dihydroorotate dehydrogenase, revealing structural insights and potential for improved antimalarial drugs.

The paper analyzes parasite genotypes in sympatric mosquito species to show divergent selection on Plasmodium falciparum mediated by different vectors.

The paper introduces a PCR-based assay that accurately distinguishes between Plasmodium ovalecurtisi and Plasmodium ovalewallikeri, with high sensitivity and specificity for malaria diagnosis.

The paper uses single-cell RNA sequencing to analyze immune cell interactions in asymptomatic and symptomatic malaria patients, finding reduced monocyte-T cell interactions and increased inflammation in symptomatic cases.

The paper shows that Microsporidia MB in wild Anopheles arabiensis mosquitoes reduces Plasmodium falciparum infection odds by up to 60% depending on symbiont intensity.

The paper argues that low diversity in pathogen proteins does not necessarily indicate evolutionary constraint and introduces a tool to explore diversity and divergence in Plasmodium falciparum proteins.

Maternal microchimerism in Malian cord blood is associated with fewer Pf-responsive ZBTB16+ CD4 and Vγ9Vδ2 T cells, and with infant malaria outcomes.

PlasmoRhythm integrates time-resolved omics data from malaria parasites, hosts, and vectors to enable comparative analysis of rhythmic molecular profiles.

The paper identifies target-site mutations and copy number variants in Anopheles gambiae s.l. from Ghana, showing their association with insecticide resistance across different intervention sites.

This paper shows that PfHSP70-3-SBD enhances PfCSP immunogenicity through cross-presentation, improving vaccine efficacy against malaria.

This study uses nanopore sequencing to determine the replication timing programme of Plasmodium falciparum and links it to DNA breaking and replication fork stalling.

The paper identifies a silent intergenic locus in Plasmodium falciparum that allows stable transgene expression without disrupting native genes, enabling versatile genetic engineering.

This study identifies potent antimalarial antibodies in African infants vaccinated with RTS,S/AS01E, showing near-germline configurations and protective efficacy.

This study identifies host adaptation barriers in Plasmodium knowlesi by analyzing multi-omic data from parasites cultured in human and macaque red blood cells.

The paper characterizes the population structure and drug resistance of Plasmodium falciparum in Uganda and neighboring countries using whole-genome data, identifying key resistance-associated haplotypes.

PfPHAST is a streamlined amplicon sequencing panel for malaria genomic surveillance, offering better quality control and cost efficiency than MAD4HatTeR without sacrificing performance on shared targets.

This paper designs de novo minibinders that inhibit blood-stage malaria replication with nanomolar potency by targeting the RH5-basigin interaction.

The paper shows that additional blood meals increase Plasmodium falciparum sporozoite infectivity to hepatocytes by altering their transcriptional profiles.

The paper surveys mosquito communities in a tropical riverine forest, finding Anopheles species near rivers and detecting simian malaria parasites, suggesting zoonotic transmission risks.

This paper shows that L-lactate promotes gametocytogenesis in Plasmodium falciparum by inducing histone lactylation and regulating the GDV-1/AP2-G epigenetic pathway.

This paper identifies MMV006833 as an inhibitor of PfSTART1 in P. falciparum but shows it is ineffective against P. berghei due to structural differences and other factors.

The paper shows that isoleucine deficiency in human hemoglobin mirrors mosquito proteomes and limits malaria parasite growth.

The study examines how immune responses in Anopheles mosquitoes correlate with Plasmodium falciparum ookinete load during early infection, finding that lower parasite loads are associated with stronger immune gene upregulation.

The paper shows that genetic background influences whether Pfkelch13 mutations confer short-term artemisinin tolerance or long-term persistence in Plasmodium falciparum.

This study shows that phosphorylation of Plasmodium falciparum MyoA at Ser19 dynamically regulates motor speed and is essential for asexual replication.