CRISPR/Cas9 genome editing to generate single variant Plasmodium falciparum lines and enable reverse genetic studies of PfEMP1 function in live parasites
Stanley E Otoboh, Hussein Molu Abkallo, Jessie Jungels…·J Alexandra Rowe
Author
University of EdinburghORCID 0000-0002-7702-1892Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Stanley E Otoboh, Hussein Molu Abkallo, Jessie Jungels…·J Alexandra Rowe
Florence McLean, Brian R. Omondi, Nouhoum Diallo…·J. Alexandra Rowe
The paper identifies novel PfEMP1 variants associated with rosetting in Plasmodium falciparum, expanding the known types of PfEMP1 that mediate this phenotype.
Florence McLean, Yvonne Azasi, Cameron Sutherland…·J. Alexandra Rowe
The paper demonstrates the presence of strain-transcending antibodies against rosetting Plasmodium falciparum strains in humans using flow cytometry and antibody elution experiments.
Ana-Maria Năstase, Michael Peter Barrett, Washington Bolivar Cardenas…·Simon Rogers
This study aligns metabolomics LC-MS datasets from malaria, leishmaniasis, and Zika virus to identify fever-associated metabolites, finding the kynurenine pathway as most affected.
D. Herbert Opi, Carolyne Ndila, Sophie M. Uyoga…·J. Alexandra Rowe
The paper investigates how non-O ABO blood group genotypes relate to Plasmodium falciparum rosetting and severe malaria risk in Kenyan children.
Silvia N. Kariuki, Alejandro Marín-Menéndez, Viola Introini…·Julian C. Rayner
The paper shows that Dantu blood group variant increases red blood cell tension, reducing Plasmodium falciparum invasion and protecting against severe malaria.